https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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‘Of course, that's about appropriate. I search for a Actual physical idea of biological programs inside of a bottom-up way. I feel you could potentially distinguish three traces of exploration in my team in the meanwhile. The initial fears chromosome structure: How can you have a metre-long DNA polymer folded and organised in this type of microscopic mobile? Now we have created visualisation strategies that make it possible for us to check how, for instance, SMC proteins loop DNA (video clip on Youtube) so as to Establish up chromosomes.
Our group research bacterial mobile division and is particularly aiming to represent a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in cell division, chromatin composition, and spatial Command.
Around the similar time, the group of Paul McEuen, who was then based for the College of California, Berkeley, showed very similar benefits on ropes of bundled nanotubes. With regards to the wrapping angle, nanotubes can come in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified utilizing scanning tunnelling spectroscopy experiments.
Deposition and atomic power microscopy of person phthalocyanine polymers involving nanofabricated electrodes
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SMC complexes can go Actual physical roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
We shape bacteria into sorts that deviate from their pure phenotype. Exclusively, I will display our ability to condition Are living E. coli micro organism into novel designs like rectangles, squares, triangles and circles.
He also observed time to put in writing quite a few textbooks, ship Nearly forty ceesdekker.net thousand tweets and guide An effective study group at Delft College of Know-how. ‘It doesn’t truly feel like get the job done’, he claims. ‘I’m just terribly curious.’
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At the moment, we also realized that it should be possible to use just one semiconducting carbon nanotube to create a transistor — and we set out to really make it. We stretched particular person semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as being a gate electrode, establishing The essential a few-terminal format of a area-effect transistor (Fig.
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Cees Dekker is Distinguished University Professor at TU Delft. Educated like a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes while in the nineties. Given that 2000, he moved to solitary-molecule biophysics and nanobiology. His existing research concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, especially SMC motor protein; and (iii) creating a residing synthetic cell from lifeless molecules. Dekker is an elected member from the KNAW and fellow towards the APS and also the IOP.
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It had been a very exciting time, throughout which I acquired a lot of help from Delft College of Technology, in which I had been a professor at some time, And that i begun numerous collaborations with molecular biologists. That aided me master a great deal.’